Menstruation Research Today is a free monthly online journal that collates and summarizes the latest research about Menstruation, including details on menstrual cycle, pregnancy, pain, irregular menstruation.

Human sperm can fertilize ova inside the Graafian follicles before ovulation.

Nada ZM, Assaf NF, Dubey SK,

IVF Center, King Fahd Specialist Hospital, Buraidah, Al-Qassim, Saudi Arabia. zmmn@hotmail.com

OBJECTIVE: To report an incidental finding of fertilization of ova inside the ovarian follicles before ovulation. DESIGN: Case report. SETTING: IVF Center, King Fahd Specialist Hospital, Buraidah, Al-Qassim, Saudi Arabia. PATIENT(S): One 31-year-old woman with 8 years of primary infertility. INTERVENTION(S): Long-protocol superovulation and ovum pickup (OPU). MAIN OUTCOME MEASURE(S): The retrieved nine oocytes were incubated and followed up closely. RESULT(S): Three hours after OPU and only after decoronization of oocytes, sperm were seen attached to the zonae pellucidae of six mature oocytes. Three of them were showing signs of fertilization (two pronuclei). Neither conventional IVF nor intracytoplasmic sperm injection was done, and we decided to continue incubation and observation of all oocytes. From the nine total oocytes, fertilization was demonstrated in six with attached sperm, of which four divided. On day 2 after OPU, three embryos were transferred into the uterus. CONCLUSION(S): Human sperm can migrate and ascend through the female genital tract to get through the ovarian tissue. Moreover, under certain conditions, it can penetrate the wall of an intact ovarian follicle to reach the ovum and fertilize it just before ovulation.

Published 11 February 2005 in Fertil Steril, 83(2): 457-61.
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